WebMay 31, 2011 · Effect of AKT on BIM phosphorylation. Cells were metabolically labeled with [32 P] orthophosphoric acid and treated with ATO (2 µM) for 48 h, and BIM was immunoprecipitated by using an agarose-conjugated BIM antibody, then detection of phosphorylation of BIM. Phosphorylation of BIM was determined by autoradiography … WebInstead, BIM is a negative regulator of autophagy due to its ability to mislocalize BECLIN1 to the dynein light chain LC8 through a direct interaction that does not involve either the BIM or BECLIN1 BH3 domains (Luo and Rubinsztein, 2013). Starvation conditions leads to JNK-mediated phosphorylation of BIM and its release, together with BECLIN1 ...
Alternative splicing of Bim and Erk-mediated Bim(EL) …
Webregulating p-AKT by activating caspase-3 and that BIM mediates the level of AKT phosphorylation to determine the threshold for overcoming cisplatin resistance in ovarian cancer cells. Citation: Yuan Z, Wang F, Zhao Z, Zhao X, Qiu J, et al. (2011) BIM-Mediated AKT Phosphorylation Is a Key Modulator of Arsenic Trioxide-Induced Apoptosis in WebFeb 16, 2012 · This is surprising because BIM L lacks the serine residue equivalent to BIM EL S 69 and the ERK docking domain required for BIM EL phosphorylation. 46 Compared with BIM EL, there was a weaker correlation between levels of BIM L and ERK1/2 phosphorylation, which may reflect a requirement for additional intermediates to … depression and anxiety call line
IJMS Free Full-Text Down-Regulation of miR-23a-3p Mediates ...
WebFeb 16, 2012 · BIM phosphorylation was dependent on MEK1/2 kinase activity, and we identified BIM(EL) serine 69, previously linked to pro-survival responses, as the major site of phosphorylation in CLL and in Ramos cells. BIM(EL)/BIM(L) phosphorylation was associated with release of the pro-survival protein MCL1. WebJun 24, 2011 · Bim phosphorylation can decrease its stability or alter its interaction with other proteins to regulate apoptosis ( 21, 22 ). A number of studies have shown that Bim can be phosphorylated by ERK and that such phosphorylation leads to ubiquitination and subsequent degradation in the proteasome ( 16, 17, 21 ). WebFeb 2, 2024 · Phosphorylation of Ser/Thr residues is a well-established modulating mechanism of the pro-apoptotic function of the BH3-only protein Bim. However, nothing is known about the putative tyrosine ... depression and anxiety awareness week 2018