WebMar 20, 2024 · The primary cilium acts as an antenna amplifying signals via G-protein coupled receptor (GPCR) activity and high concentrations of intraciliary calcium that shift membrane polarization, allowing the neuron to integrate local environmental metabolic cues to inform downstream activity. WebThe authors observe intriguing brain-region-specific differences in ciliary localization of the above GPCR pathways’ components and demonstrate that BBSome may control ciliary entry/retention of Sstr3 and Mchr1 and exit of D1, Gpr161, and Gpr19, thus revealing additional complexity in protein- and cell-type-specific mechanisms guiding ciliary ...
Editorial: Signaling by primary cilia in development and disease
WebMultiple G protein-coupled receptors (GPCRs) are expressed in pancreatic islet cells, but the majority have unknown functions. We observed specific GPCRs localized to primary cilia, a prominent signaling organelle, in pancreatic α and β cells. ... Transport of GPCRs to primary cilia requires TULP3, whose knockdown in primary human and mouse ... A cilium is assembled and built from a basal body on the cell surface. From the basal body the ciliary rootlet forms ahead of the transition plate and transition zone where the earlier microtubule triplets change to the microtubule doublets of the axoneme. The foundation of the cilium is the basal body, a term applied to the mother centriole when it is associated with a cilium. Mammalian basal bodies consist of a barrel of nine triplet microtubules… chitown liquid suntans
Cilia regeneration in the sea urchin embryo: evidence for a
WebJan 13, 2024 · Ciliary ectosomes are enriched in a subset of ciliary membrane proteins, proteases, proteins from the endosomal sorting complex required for transport, small GTPases, and ubiquitinated … WebApr 8, 2024 · Here, we genetically inactivated mouse Tmem138, a gene encoding a putative transmembrane protein localized to the ciliary TZ and linked to ciliopathies. Germline deletion of Tmem138 abolished OS … WebThe cilium membrane, although continuous with the plasma membrane, possesses a specific and conserved composition of proteins and lipids. This specification is established through an active... chi town lady horse profile