Web摘要：The case is reported of a 74-year old man with symmetrical purpura which accompanied essential cryoglobulinaemia. The purpura could be precipitated by exposure to cold. Serum cryoglobulin could not always be demonstrated. There was no evidence of haemophilia and cold-agglutinins could not be demonstrated. INTRODUCTION Cold agglutinin disease (CAD) is a form of acquired autoimmune hemolytic anemia (AIHA) in which cold exposure can cause clinical symptoms related to agglutination of red blood cells (RBCs) in cold parts of the body (eg, livedo reticularis or acrocyanosis) and … See more The vast majority of cold agglutinins are directed against \"I\" or \"i\" antigens of the I blood group (referred to as \"big I\" or \"little i\" … See more In certain settings, the antigen may suggest a specific infectious cause (eg, the antibodies are usually directed against I in Mycoplasma pneumoniae infection and against i in infectious mononucleosis), as outlined in the table … See more The big I and little i antigens are ubiquitous (present on all cell membranes) and structurally related [3-5]. Little i is the predominant structure on fetal RBCs. It consists of a straight … See more These complex polysaccharides also serve as precursors for the assembly of the ABO and Lewis blood group antigens. Sometimes, the epitope of particular anti-I or anti-i antibodies may include parts of the ABO or Lewis … See more

Cold agglutinin disease and cryoglobulinemia - PubMed

WebCryoglobulins and cold agglutinins for hand arm vibration syndrome Cryoglobulins and cold agglutinins for hand arm vibration syndrome Occup Med (Lond). 2024 Sep 30;kqac083. doi: 10.1093/occmed/kqac083. Online ahead of print. Authors Y Alsaidi 1 , A Thompson 1 , V Spilchuk 1 , R A House 1 , A Adisesh 1 Affiliation WebRose Ruchlemer is an academic researcher. The author has contributed to research in topic(s): Vignette. The author has an hindex of 1, co-authored 1 publication(s) receiving 5 citation(s). thous five

National Center for Biotechnology Information

WebCold agglutinins are autoantibodies that agglutinate red blood cells at an optimum temperature of 3°C to 4°C. Cold agglutinin disease (CAD) affects about 15% of patients … WebRørvik believes that the cold agglutinins present behaved as cryoglobulins. No studies were performed to clarify this point. The relation of cold agglutinins and cryoglobulins … WebRituximab therapy has been found to be effective in mixed cryoglobulinemia, with decreases in cryoglobulin values and improvement in complement values. AB - Cold agglutinin disease is a form of direct, extravascular, antiglobulin-positive hemolysis. In vivo, immunoglobulin (Ig) M fixes complement molecules to the red cell membrane. under the dome episode 4