Crystallin promoter
WebEarlier experiments showed that the betaB1-crystallin promoter sequence from -120 to -48 contains a cis element (PL2 at -90 to -76) that stimulates the activity of a heterologous promoter in lens cells but not in fibroblasts. WebMar 21, 2024 · Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell …
Crystallin promoter
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WebThe two paralogous zebrafish αB-crystallin promoters produced subtly different expression profiles, with the aBa promoter driving expression equally in notochord and skeletal muscle while the αBb promoter resulted primarily in skeletal muscle expression. Webgene-specific sequences such as the gene-specific promoter sequence in the proximal promoter of the small heat shock protein gene, alpha B-crystallin (cryab) , may have critical roles in regulating gene-specific activity from eukaryotic promoters. AlphaB-crystallin is a novel regulator of brain metastasis in triple-negative breast cancer.
WebA conserved and essential DNA motif in the promoters of the γ-crystallin genes is the binding site of the SOX proteins that activate the promoters (Kamachi et al., 1995). … WebMay 4, 2006 · Dramatic upregulation of αA-crystallin expression is associated with primary lens fiber cell differentiation. Previous studies have shown that a −366 to +46 αA …
WebApr 8, 2024 · Further explorations unveiled the increased MAF in high myopia and its participation in a direct activation of crystallin promoters and an indirect activation via … WebSep 1, 2002 · Thus, the chicken betaB1-crystallin promoter directs high level RNA expression to lens fiber cells, which may be especially useful for the expression of ribozyme and anti-sense RNAs in addition to ...
WebFeb 21, 2024 · The predicted promoter probability and location, and the type of the mutation are shown above each sequence (TSS at position 100). b–d, TERT promoter point mutations predicted by the CNN model...
WebDec 29, 2008 · The scallop Ω-crystallin promoter sequence contains an abundance of motifs that are similar to those in vertebrate crystallin promoters. These include cis … cuny womens volleyballWebDec 3, 2013 · CpG island methylation in the αA-crystallin promoter was similar in age-related cataract and high-myopic cataract classified as Lens Opacity Classification System III Grade Nuclear Color 2–3. Pyrosequencing, a real-time DNA sequencing method, was used to determine single-base variations caused by CpG methylation of the CRYAA … cuny women\\u0027s conference 2023WebDec 1, 2012 · The gene promoter contains response elements for some key transcription factors essential for normal lens development. Prominent among these are factors such as Pax6, c-Maf, Sox2, Prox1, and Six3 [93,94]. In many crystallin gene promoters, elements for lens and non-lens expression are combined in the same 5 ′ region. easy blackberry muffins recipeWebCrystallin promoters of widely different species are dependent on the same suite of transcription factors and function in similar ways in lens-cells of other species both in culture and in transgenic models (for example: [31–33]). This allows comparison of promoters from both chicken and mouse in mouse cells. easy blackberry jelly recipesWebJul 5, 2002 · Crystallin promoter reporters. The constructs with the αA-, βB2-, and γF-crystallin promoters linked to a luciferase reporter are depicted. Potential c-Maf recognition sites are located at −110 to −98 in the αA and βB2 promoters, and at −47 to −35 in the γF promoter ( 30, 31, 32 ). easy blackberry crumble recipeWebThe inclusion of a Pax6 consensus binding site within the -282/+43 alphaA-crystallin promoter enhances the ability of this promoter to drive transgene expression in the lens … easy blackberry jam recipe without pectinWebRetrospectively from the results of ( Maf) knock-out mice. it was also shown that MAF binds the promoter sequences of some, B-crystallin promoters ( Ring et al., 2000 ). Three … easy blackberry snacks