Mitoferrin 1
Web11 apr. 2024 · A metabolism-focused CRISPR screening using Jurkat leukemia cells revealed that the loss of either of two mitoferrin isoforms, MFRN-1 (SLC25A37) or MFRN-2 (SLC25A28), sensitizes cells to GPX4 inhibition–induced ferroptosis , which suggests that the mitochondrial import of iron (perhaps because it is sequestered in the mitochondrial … WebMitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier family. Mitoferrin 1 is required for mitochondrial iron delivery in developing erythrocytes. …
Mitoferrin 1
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Web15 aug. 2016 · Mitoferrin 1 has been reported to be both alternatively spliced and differentially expressed in SF3B1-mutant MDS 13,42. We noted Mitoferrin 1 demonstrated differential splicing in SF3B1 K700E as well as in MDS patient samples, albeit with only small differences in splicing ratio (Figure 5E&F).
Web"Mitoferrin 1 antibodies" comparison. At Proteintech, we pride ourselves on our antibody quality, customer service and transparency. As such, we are comparing our antibodies with other vendors, enabling easy identification and comparisons of key data to help you choose the suitable antibody for your needs. WebMitoferrin-1 belongs to the mitochondrial carrier family. It specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. Mitoferrin-1, also known as mitochondrial iron transporter 1, is found on the inner mitochondrial membrane. It is member 27 of solute carrier family 25.
Web1 feb. 2024 · Two mitoferrin proteins, mitoferrin-1 (MFRN1; encoded by the solute carrier family 25-member 37 gene [SLC25A37]) and mitoferrin-2 (MFRN2; encoded by SLC25A28), are the most significant mitochondrial iron importers [16,17] and are critical regulators of cytosol-mitochondria iron homeostasis in human cells [18,19,20,21]. Web0.2ml Mitoferrin 1 线粒体铁转运蛋白1抗体 96T/48T 0.5mg 0.2ml PIGA 红细胞磷脂酰肌醇聚糖A抗体 96T/48T 0.5mg 0.2ml Factor H 补体因子H抗体 96T/48T 0.5mg 0.2ml EKLF/KLF1, 2, 4 上皮锌指蛋白1, 2, 4抗体 96T/48T 0.5mg
Web19 mei 2011 · The murine Mfrn1 (Slc25a37) gene consists of 4 exons spread over more than 43 kb on mouse chromosome 14 on the reverse strand, with exon 1 far from the …
Web17 jun. 2013 · Mitoferrin-1 transports iron to ferrochelatase in the mitochondria of cells for heme formation, and also transports iron for the formation of a compound that keeps ferrochelatase active and stable. Thus, a deficiency of this iron transporter could reduce ferrochelatase activity and contribute to the phenotype in EPP. how to do cat\u0027s stretch yoga poseWebmitoferrin Introduction Head and neck cancer, including cancers of the mouth, nose, oral cavity, and throat, is the sixth most common cancer worldwide ( 1 ). Current treatments for head and neck cancers include … the nature debateWeb11 nov. 2024 · 4.2. Mitoferrin-1 and electron transport chain (ETC) In the present study, we applied the analysis of mitochondrial O 2 consumption as a sensitive measure to detect a … how to do cathfloWeb21 jun. 2010 · Protein players in mitochondrial iron transport and metabolism (Figure 1) include mitoferrins (iron transport into mitochondria), frataxins (delivery or iron to Fe-S cluster scaffolding proteins), Fe-S cluster scaffolding proteins (generation of Fe-S cofactors), and mitochondrial ferritin (iron sequestration) [ 1 ]. Figure 1 how to do catch stitchWebMitoferrin-1 (UniProt Q920G8; also known as mitochondrial iron transporter 1, mitochondrial solute carrier protein, solute carrier family 25 member 37) is encoded by … the nature conservancy terrestrial resilienceWeb2 mrt. 2006 · Nature - Mitoferrin is essential for erythroid iron assimilation. ... (Zv5_scaffold 431.1), was homologous to mitochondrial solute transporters (SLC25) 6 in Schizosaccharomyces pombe (SPAC8C9.12C). how to do categories in outlookWeb10 aug. 2024 · In mammals, mitoferrin-1 and mitoferrin-2, two homologous proteins of the mitochondrial solute carrier family are required for iron delivery into mitochondria. … how to do catering business